Serrapep+
Serratiopeptidase is a proteolytic enzyme (protease) produced in the laboratory by Enterobacterium Serratia sp. E-15 from plant material. This microorganism was originally isolated in the late 1960:s from the intestine of silkworm Bombyx mori. Serratiopeptidase allows the emerging moth to dissolve its cocoon. Serratiopeptase is produced by purification from culture of Serratia E-15 bacteria
Physical and chemical properties
The product is grayish brown or brown powder, soluble in water, insoluble in methanol, and be stable within the condition of PH 5.5~8.5.
Pharmacological
- Dissolve phlegm, eliminate mucosa swelling respiratory tract, promote wound healing
- Anti-inflammatory
- Enhance the efficacy of antibiotics
- Decompose protein, increase protein conversion rate
Effect of serrapeptase supplementation on broiler performance
| Parameters | Groups | |||
|---|---|---|---|---|
| 1 Control non infected, non treated | 2 infected, non treated | 3 Infected; treated (ciprofloxacin + Serratiopeptidase 2g / L) |
4 Infected; treated (ciprofloxacin + Serratiopeptidase 1g / L) |
|
| Initial body weight | 41.22 | 41.44 | 41.26 | 41.22 |
| Final body weight | 1380.00±49.71a | 1290.00±54.46b | 1421.00±46.87a | 1357.00±51.92a |
| Weight gain | 1338.78±49.54a | 1248.56±54.27a | 1379.74±46.71a | 1315.78±51.74a |
| Relative growth rate | 188.30±0.42ab | 187.11±0.46b | 188.51±0.40a | 187.85±0.44ab |
| Feed intake | 2179.00±0.00c | 2264.00±0.00a | 2070.00±0.00d | 2248.00±0.00b |
| Feed conversion ratio | 1.63±0.07bc | 1.81±0.08a | 1.50±0.07c | 1.71±0.08ab |
| Mortality rate | 11.11% | 25.90% | 0 | 11.11% |
Effect of serrapeptase on serum proteins of broiler
| Parameters | Groups | |||
|---|---|---|---|---|
| 1 Control non infected, non treated | 2 infected, non treated | 3 Infected; treated (ciprofloxacin + Serratiopeptidase 2g / L) |
4 Infected; treated (ciprofloxacin + Serratiopeptidase 1g / L) |
|
| Total protein (mg/dl) | 8.02±0.18a | 6.86±0.11c | 7.88±0.17ab | 7.81±0.15ab |
| Albumin (mg/dl) | 4.48±0.18a | 2.67±0.09b | 4.52±0.16a | 4.50±0.18a |
| Globulin (mg/dl) | 3.54±0.08b | 4.19±0.06a | 3.36±0.13bc | 3.31±0.05bc |
Effect of serrapeptase treatment on serum lipids of broiler
| Parameters | Groups | |||
|---|---|---|---|---|
| 1 Control non infected, non treated | 2 infected, non treated | 3 Infected; treated (ciprofloxacin + Serratiopeptidase 2g / L) |
4 Infected; treated (ciprofloxacin + Serratiopeptidase 1g / L) |
|
| Total lipids (mg/dl) | 330.23±3.52c | 394.42±4.32a | 363.16±2.45b | 360.28±2.36b |
| Total cholesterol (mg/dl) | 141.23±2.57b | 166.34±3.65a | 139.41±3.58b | 137.25±3.29b |
| Triglycerides (mg/dl) | 115.12±4.62a | 118.34±3.67a | 113.91±5.48a | 116.12±3.25a |
Effect of serrapeptase treatment on serum enzyme markers for inflamemation
| Parameters | Groups | |||
|---|---|---|---|---|
| 1 Control non infected, non treated | 2 infected, non treated | 3 Infected; treated (ciprofloxacin + Serratiopeptidase 2g / L) |
4 Infected; treated (ciprofloxacin + Serratiopeptidase 1g / L) |
|
| LDH (U/L) (lactate dehydrogenase) | 103.63±5.67b | 125.24±6.24a | 86.55±4.51c | 70.86±5.59d |
| CRP (mg/L) (C Reactive protein) | 8.87±1.18d | 72.86±4.65a | 43.59±3.87b | 26.93±3.54c |
| ESR (mm/hr) (erythrocyte sedimentation rate) | 15.12±2.33b | 44.34±4.72a | 18.87±3.39b | 13.69±2.67b |
Effect of serrapeptase treatment on liver function enzymes
| Parameters | Groups | |||
|---|---|---|---|---|
| 1 Control non infected, non treated | 2 infected, non treated | 3 Infected; treated (ciprofloxacin + Serratiopeptidase 2g / L) |
4 Infected; treated (ciprofloxacin + Serratiopeptidase 1g / L) |
|
| ALT (U/L) | 38.46±4.55b | 51.53±2.34a | 37.72±2.43b | 36.23±2.51b |
| AST (U/L) | 67.14±6.53b | 83.31±7.21a | 69.42±4.35b | 65.64±3.57b |
| ALP (U/L) | 103.31±7.64a | 108.18±8.84a | 105.66±5.52a | 102.82±6.73a |
Effect of serrapeptase treatment on (log2) HI titers, air sac lesion scores at 35 days of age and re-isolation of E.coli and MG
| Parameters | Groups | |||
|---|---|---|---|---|
| 1 Control non infected, non treated | 2 infected, non treated | 3 Infected; treated (ciprofloxacin + Serratiopeptidase 2g / L) |
4 Infected; treated (ciprofloxacin + Serratiopeptidase 1g / L) |
|
| HI titers of ND | 26.6 | 26 | 27.3 | 25.3 |
| Air sac lesion scoring | 0 | 3 | 1 | 2 |
| MG re-isolation | 0% | 100% | 33.30% | 66.60% |
| E. coli re-isolation | 0% | 100% | 66.60% | 66.60% |
Usage and dosage
Mixed with drinking water. Poultry, using this product 3000~5000u/kg body weight. One day has 24hours, expect for using others medicines’ time, at others time drink freely. It’s better to use medicine different with others medicine’s time.
Storage
Store in a cool and dry place.